Nanosized Carotenoid Cyclodextrin Complexes
AssigneeNSE Products, Inc.
InventorsMark Bartlett, Angela Mastaloudis, Carsten Smidt, Stephen Poole
Life of this patent
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Abstract
Methods for the preparation of nanosized nutrient formulations for enhanced absorption of nutritional agents. The methods include the complexation of cyclodextrin with carotenoids and incorporation of the complexes into the nutritional supplements without intermediate collection, isolation, and drying steps.
Claims28
A method of manufacturing a carotenoid containing nutritional supplement comprising:
- a) mixing an amount of cyclodextrin with water to form a water/cyclodextrin slurry at 50° C.
- b) admixing an amount of at least one carotenoid to the water/cyclodextrin slurry to form a preblend composition including cyclodextrin carotenoid complexes
- c) pulling a vacuum over the preblend composition and thoroughly mixing the preblend composition for a minimum of 1 hour
- d) forming a final blend by mixing under a vacuum the undried preblend composition with additional nutritional components at a temperature of about 40° C. to 45° C.
- e) milling the final blend in a vacuum
- f) encapsulating the milled final blend.
A method for manufacturing a carotenoid containing nutritional supplement comprising:
- a) heating an amount of water to 50° C. in a blending apparatus
- b) mixing an amount of cyclodextrin with water to form a water/cyclodextrin slurry
- c) admixing an amount of at least one carotenoid to the water/cyclodextrin slurry to form a preblend composition including cyclodextrin carotenoid complexes
- d) pulling a vacuum over the preblend composition and thoroughly mixing the preblend composition for a minimum of 1 hour
- e) in a separate mixing container, warming an amount of fish oil to a temperature to 40° C. to 45° C.
- f) forming a final blend by mixing under a vacuum the undried preblend composition with the fish oil at a temperature of about 40° C. to 45° C.
- g) optionally admixing additional nutritional components to the final blend
- h) cooling final blend mixture to 25° C. to 28° C.
- i) milling the final blend in a vacuum to reduce particle size
- j) encapsulating the milled final blend.
A carotenoid containing composition comprising:
- at least one carotenoid;
- a cyclodextrin;
- and
- fish oil, wherein the fish oil comprises from 70 wt % to 90 wt % of the composition.
A method of enhancing bioavailability of a carotenoid, comprising:
- co-administering to a subject in need thereof an a carotenoid and a combination of a cyclodextrin and fish oil.
Dependencies are inferred from the claim text.