Purine derivatives and methods of use thereof

A compound having the formula

• or a pharmaceutically acceptable salt thereof,
• wherein
• A is —CH2OH;
• B and C are—OH;
• D is
• A and B are trans with respect to each other;
• B and C are cis with respect to each other;
• C and D are cis or trans with respect to each other;
• R1 is —H, -halo, —CN, —N(R2)2, —OR2, —SR2, —NHC(O)R2, —NHC(O)N(R2)2, —NHC(O)OR2, —C(O)OR2, —C(O)R2, —C(O)N(R2)2, —OC(O)N(R2)2, —C(halo)3, or —NO2;
• each R2 is independently —H, —C1-C10 alkyl, —C2-C6 alkenyl, —C2-C6 alkynyl, —(CH2)n-aryl, —(CH2)n-(3- to 7-membered monocyclic heterocycle), —(CH2)n-(8- to 12-membered bicyclic heterocycle), —(CH2)n—(C3-C8 monocyclic cycloalkyl), -(CH2)n—(C3-C8 monocyclic cycloalkenyl), —(CH2)n—(C8-C12 bicyclic cycloalkyl), or —(CH2)n—(C8-C12 bicyclic cycloalkenyl);
• each n is an integer ranging from 0 to 6;
• each p is an integer ranging from 1 to 6;
• and
• each q is an integer ranging from 1 to 6.