Methods for Modulating IKKalpha Activity
AssigneeBoehringer Ingelheim International GmbH
InventorsJun Li, Xiang Li, Jianfei Yang, Kenneth Marcu
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Abstract
A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription.
Claims24
A method of modulating NF-κB dependent gene expression in a cell said method comprised of modulating IKKα activity in the cell.
A method for selectively modulating expression of a gene whose expression is regulated by IKKα, the method comprising modulating IKKα activity such that expression of said gene is modulated.
An siRNA composition comprised of siRNA sequence selected from the list consisting of SEQ. ID NO. 2, SEQ. ID NO. 3, SEQ. ID NO. 4, SEQ. ID NO. 5, SEQ. ID NO. 6, or SEQ. ID NO. 7.
A method for treating autoimmune and inflammatory disease in a mammal said method comprised of modulating the expression or activity of IKKα.
A method for identifying a compound for the treatment of autoimmune and inflammatory disease, said method comprised of the steps of:
- a) incubating an IKKα protein in the presence of a potential inhibitor of IKKα activity;
- b) measuring the loss of IKKα activity;
- c) comparing the amount of IKKα activity present in the absence of a potential inhibitor.
An siRNA compound 21-25 nucleotides in length that specifically hybridizes to a nucleic acid molecule encoding human IKKα of SEQ. ID. No. 1.
Dependencies are inferred from the claim text.