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US 2007/0191298 A1Published application
Beta Secretase Genes
AssigneeAmgen Inc.
InventorsMartin Citron, Robert Vassar, Brian Bennett
Life of this patent
Estimating the term…
Abstract
Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
Claims13
1-21. (canceled)
An isolated nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid molecule encoding the polypeptide of SEQ ID NO:
- 4;
- b) a nucleic acid molecule encoding a polypeptide having one to fifty conservative amino acid substitutions as compared with the polypeptide of SEQ ID NO:4, wherein the polypeptide encoded by said nucleic acid molecule is biologically active and comprises the transmembrane domain;
- c) a nucleic acid molecule of the DNA vector insert of ATCC Deposit No. 207159;
- and
- d) a nucleic acid molecule that is the complement of any of (a)-(c) above.
3 more elements
An isolated nucleic acid molecule selected from the group consisting of:
- a) the nucleic acid molecule as set forth in any of SEQ ID NO:
- 1;
- b) a nucleic acid molecule encoding the polypeptide of SEQ ID NO:
- 4;
- c) a nucleic acid molecule of the DNA vector insert of ATCC Deposit No. 207159;
- d) a nucleic acid molecule encoding a polypeptide having one to fifty conservative amino acid substitutions as compared with the polypeptide of SEQ ID NO:4, wherein the polypeptide encoded by said nucleic acid molecule is biologically active and comprises the transmembrane domain;
- and
- e) a nucleic acid molecule that is the complement of any of (a)-(d) above.
5 more elements
A nucleic acid molecule that is SEQ ID NO:
- 1.
A nucleic acid molecule encoding the polypeptide of SEQ ID NO:4.
Dependencies are inferred from the claim text.