Injectable composition
AssigneeTakeda Pharmaceutical Company Limited
InventorsTakayuki Doen, Tomoko Inoue
Life of this patent
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Abstract
An injectable composition comprising a combination of 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole (lansoprazole), its optically active compound or a salt thereof, and a chelating agent, which is used at pH 9 to 12. The injectable composition is excellent in stability and solubility, and has such a high-quality that particulate insolubles are not formed when the composition is kept and supplied in a glass container and even in a plastic container and also when the composition is kept in these container for a long time.
Claims21
An injectable composition comprising a combination of 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole (lansoprazole), its optically active compound or a salt thereof, and a chelating agent, which is used at pH 9 to 12.
An injectable composition comprising a solution of lansoprazole, its optically active compound or a salt thereof and a chelating agent, which is substantially free of insolubles and filled in a container, and which is used at pH 9 to 12.
An injectable composition which is prepared by adding an aqueous or a non-aqueous solvent containing edetic acid or its salt to a freeze-dried injectable preparation containing 30 mg of lansoprazole, its optically active compound or a salt thereof, about 3 mg to about 10 mg of sodium hydroxide, about 8 mg to about 24 mg of N-methylglucamine and 60 mg of mannitol.
Dependencies are inferred from the claim text.