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US 2007/0191281 A1Published application
Compound containing a labile disulfide bond
OwnerJon Wolff, Sean Monahan +3inventors
InventorsJon Wolff, Sean Monahan, Vladimir Budker, Paul Slattum, David Rozema
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Abstract
A labile disulfide-containing compound under physiological conditions containing a labile disulfide bond and a transduction signal.
Claims6
A process for delivering a compound having a labile disulfide bond into a mammal, comprising:
- a) forming the compound having a disulfide bond selected from the group consisting of (i) a disulfide bond that is cleaved more rapidly than oxidized glutathione, and (ii) a disulfide bond constructed from thiols in which one of the constituent thiols has a lower pKa than glutathione, and (iii) a disulfide bond that is activated by intramolecular attack from a free thiol;
- b) attaching a transduction signal to the compound;
- c) inserting the compound into the mammal;
- and,
- d) releasing the bond between the sulfur atoms in the disulfide.
2 more elements
Dependencies are inferred from the claim text.