Methods and compositions for treating disorders associated with increased bone turnover and osteopenia
AssigneeNew York University
InventorsBruce Cronstein, Firas Kara
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Abstract
The invention provides methods and compositions for modulating osteoclastogenesis and for treating bone diseases characterized by bone loss or a decrease in bone mass or density, by administering a compound or agent that modulates the adenosine A1 receptor, in particular, an inhibitor or antagonist of the A1 receptor.
Claims55
A method for inhibiting osteoclast differentiation, formation, or function, comprising administering an agent that blocks or antagonizes an adenosine receptor, in an amount sufficient to inhibit osteoclast differentiation, formation or function.
A method of increasing bone mass or ameliorating loss of bone mass in a subject suffering from a condition characterized by low bone mass, or for treating a subject having a disease or condition characterized by bone loss or low bone mass, or for preventing the condition in a subject prone to developing said condition, the method comprising administering to said subject a therapeutically effective amount of an adenosine receptor antagonist, or an analog, derivative or combination thereof.
A pharmaceutical composition for inhibiting the differentiation, formation or function of osteoclasts, comprising an adenosine receptor antagonist and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.