Compositions and therapeutic methods using morphogenic proteins, hormones and hormone receptors
OwnerJohn Lee, Lee-Chuan Yehinventors
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Abstract
This invention features devices and methods for inducing tissue formation in a mammal, involving the use of a morphogenic protein, a hormone and a soluble receptor of the hormone. The hormone and receptor thereof are used to enhance the tissue inductive activity of the morphogenic protein.
Claims27
A method for improving the tissue inductive capability of a morphogenic protein at a target locus in a mammal, the method comprising administering to the target locus the morphogenic protein and a first effective amount of a hormone and a second effective amount of a soluble receptor of the hormone, wherein the morphogenic protein is capable of inducing tissue formation when accessible to a progenitor cell in the mammal, and the hormone and the receptor in combination enhance that capability.
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A pharmaceutical composition for inducing tissue formation in a mammal, comprising a morphogenic protein, a hormone and a soluble receptor of the hormone, wherein the morphogenic protein is capable of inducing tissue formation when accessible to a progenitor cell in the mammal, and the hormone and the receptor in combination enhance that capability.
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A method for improving the tissue inductive activity of a morphogenic protein at a target locus in a mammal, the method comprising
- administering to the target locus a nucleic acid encoding the morphogenic protein, a nucleic acid encoding a hormone and a nucleic acid encoding a soluble receptor of the hormone, wherein the encoded morphogenic protein has tissue inductive activity when accessible to a progenitor cell in the mammal, and the encoded hormone and the encoded receptor in combination synergistically enhance the tissue inductive activity of the morphogenic protein.
Dependencies are inferred from the claim text.