Active hedgehog protein conjugate
OwnerAngelika Esswein, Kurt Lang +2inventors
InventorsAngelika Esswein, Kurt Lang, Petra Rueger, Tilman Seytter
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Abstract
A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.
Claims12
A hedgehog conjugate, comprising from 1 to 4 moieties covalently bound to a hedgehog protein;
- wherein each moiety is:
- a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or of amino acids which form transmembrane helices and are positively charged,
- b) an aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 8 to 24 C atoms and with a hydrophobic action, or
- c) a hydrophobic thio group.
A hedgehog protein, wherein the thiol group of the N-terminal cysteine is coupled to a thiol-protecting group or said hedgehog protein is a homodimer wherein the N-terminal cysteines are linked via a disulfide bridge.
A hedgehog conjugate comprising from 1 to 4 moieties covalently bound to a hedgehog protein wherein each moiety is:
- a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or of amino acids which form transmembrane helices and are positively charged,
- b) an aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 8 to 24 C atoms and with a hydrophobic action, or
- c) a hydrophobic thio group.
Dependencies are inferred from the claim text.