Method for stabilizing polypeptides lacking methionine
AssigneeDow Pharmaceutical Sciences, Inc.
InventorsJames Mayhew, Hali Wagner
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Abstract
Methionine is an effective antioxidant for polypeptides having an amino acid sequence lacking methionine. Compositions containing polypeptides having an amino acid sequence that is free of methionine residues are stabilized from oxidative degradation by combining methionine in the composition in an amount effective to inhibit oxidation of the polypeptide.
Claims14
A method for inhibiting degradation of a liquid or semi-solid composition containing a polypeptide having an amino acid sequence that does not include methionine, comprising combining free methionine in the composition in an amount sufficient to inhibit oxidation of the polypeptide.
A composition comprising a polypeptide having an amino acid sequence that is free of methionine and free methionine at a concentration that is effective to inhibit degradative oxidation of the polypeptide.
Dependencies are inferred from the claim text.