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US 2007/0190636 A1Published application
Systems and methods for ex-vivo organ care
AssigneeTransmedics, Inc.
InventorsWaleed Hassanein, Thomas Bishop, Richard Bringham, Giovanni Cecere, Robert Fishman, Larry Goff, Tamer Khayal, Stanley Kyi, Burt Ochs, Scott Newell, Ronald Taylor, Hassam Algamil, Robert Havner, Dmitri Menn
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Abstract
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
Claims78
A method of preserving a heart ex vivo comprising,
- placing a heart in a protective chamber of a portable organ care system,
- pumping a perfusion fluid to the heart, the perfusion fluid being at a temperature of between about 25° C. and about 37° C., and at a volume of between about 200 ml/min and about 5 L/min,
- monitoring one or more physiologic characteristics of the heart while it is beating in the protective chamber, and
- adjusting a pumping characteristic based at least in part on the physiologic characteristics to preserve the heart ex vivo.
1 more element
A method of preserving a heart ex vivo comprising,
- placing a heart on one or more electrodes in a protective chamber of a portable organ care system,
- pumping a perfusion fluid to the heart, the perfusion fluid being at a temperature of between about 25° C. and about 37° C., and at a volume of between about 200 ml/min and about 5 L/min, and
- monitoring electrical signals from the electrodes while pumping the perfusion fluid to the heart to preserve the heart ex vivo.
A method of transporting a heart ex vivo comprising,
- placing a heart for transplantation in a protective chamber of a portable organ care system,
- pumping a perfusion fluid into the heart via retrograde perfusion of an aorta of the heart,
- providing a flow of the perfusion fluid away from the heart via a right ventricle of the heart, and
- transporting the heart in the portable organ care system from a donor site to a recipient site while pumping the perfusion fluid into the heart via retrograde perfusion of the aorta and providing the flow of the perfusion fluid away from the heart via the right ventricle.
1 more element
A method of preserving a heart ex vivo comprising,
- placing a heart in a protective chamber of a portable organ care system,
- providing a perfusion fluid to the heart while the heart is in the protective chamber, and
- flowing the perfusion fluid to the heart through a channel formed between two heated plates to heat the perfusion fluid to a temperature of between about 32° C. and about 37° C. to preserve the heart ex vivo.
A method of evaluating a heart for transplantation comprising,
- placing a heart in a protective chamber of a portable organ care system,
- pumping a perfusion fluid into the heart via retrograde perfusion of an aorta of the heart,
- providing a flow of the perfusion fluid away from the heart via a right ventricle of the heart,
- transporting the heart via the portable organ care system from a donor site to a recipient site while pumping the perfusion fluid into the heart via the aorta and providing the flow of the perfusion fluid away from the heart via the right ventricle,
- prior to transplanting the heart into a recipient, operating a flow control external to the protective chamber to alter a flow of the perfusion fluid such that the perfusion fluid is pumped into the heart via a left atrium of the heart and is flowed away from the heart via the right ventricle and the left ventricle of the heart, and
- performing an evaluation of the heart.
3 more elements
A method of providing therapy to a heart comprising,
- placing a heart in a protective chamber of a portable organ care system,
- pumping a perfusion fluid into the heart via retrograde perfusion of an aorta of the heart,
- providing a flow of the perfusion fluid away from the heart via a right ventricle of the heart, and
- administering one or more of immunosuppressive treatment, chemotherapy, gene therapy and irradiation therapy to the heart while the perfusion fluid is pumped into the heart via retrograde perfusion of the aorta.
1 more element
A method of transplanting a heart comprising,
- arresting a heart of a donor,
- explanting the heart from the donor,
- transferring the heart to an organ care system,
- pumping a perfusion fluid to the heart in less than 30 minutes after explanting the heart from the donor, the perfusion fluid being at a temperature of between about 32° C. and about 37° C.
1 more element
A method of transplanting a heart comprising,
- explanting the heart from the donor and transferring the heart to an organ care system without arresting the heart, and
- pumping a perfusion fluid to the heart in less than 30 minutes after explanting the heart from the donor, the perfusion fluid being at a temperature of between about 32° C. and about 37° C.
A method of evaluating a heart for transplantation comprising,
- placing a heart in a protective chamber of a portable organ care system,
- pumping a perfusion fluid into the heart via a ventricle of the heart for a period of at least about 12 hours, the perfusion fluid being at a temperature of between about 32° C. and about 37° C., and
- performing an HLA test on the heart while the perfusion fluid is pumping.
Dependencies are inferred from the claim text.