Long-acting polypeptides and methods of producing same
AssigneeModigene Inc
InventorsFuad Fares, Udi Eyal Fima
Life of this patent
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Abstract
A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a peptide-of-interest are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
Claims36
A polypeptide comprising a peptide of interest and at least two chorionic gonadotrophin carboxy terminal peptides, wherein a first chorionic gonadotrophin carboxy terminal peptide of said at least two chorionic gonadotrophin carboxy terminal peptides is attached to an amino terminus of said peptide of interest, and a second chorionic gonadotrophin carboxy terminal peptide of said at least two chorionic gonadotrophin carboxy terminal peptides is attached to a carboxy terminus of said peptide of interest.
A polynucleotide comprising a coding portion encoding a polypeptide, said polypeptide comprising a peptide of interest and at least two chorionic gonadotrophin carboxy terminal peptides, wherein a first chorionic gonadotrophin carboxy terminal peptide of said at least two chorionic gonadotrophin carboxy terminal peptides is attached to an amino terminus of said peptide of interest, and a second chorionic gonadotrophin carboxy terminal peptide of said at least two chorionic gonadotrophin carboxy terminal peptides is attached to the carboxy terminus of said peptide of interest.
A method of treating or reducing the incidence associated with a growth, weight-related, or metabolic condition in a subject, said method comprising administering to said subject a therapeutically effective amount of a polypeptide, said polypeptide comprising:
- (a) a peptide of interest and (b) at least two chorionic gonadotrophin carboxy terminal peptides, wherein:
- a first chorionic gonadotrophin carboxy terminal peptide of said at least two chorionic gonadotrophin carboxy terminal peptides is attached to an amino terminus of said peptide of interest, and a second chorionic gonadotrophin carboxy terminal peptide of said at least two chorionic gonadotrophin carboxy terminal peptides is attached to the carboxy terminus of said peptide of interest,
- thereby treating said subject having a growth, weight-related, or metabolic condition.
A method of improving a biological half life of a peptide of interest, comprising the step of attaching a first chorionic gonadotrophin carboxy terminal peptide to an amino terminus of said peptide of interest and a second chorionic gonadotrophin carboxy terminal peptide to the carboxy terminus of said peptide of interest, thereby improving a biological half life of a peptide of interest.
A method of administering a peptide of interest to a subject in need thereof, comprising the step of attaching a first chorionic gonadotrophin carboxy terminal peptide to an amino terminus of said peptide of interest and a second chorionic gonadotrophin carboxy terminal peptide to the carboxy terminus of said peptide of interest, thereby generating an improved polypeptide for administration to said subject, thereby administering a peptide of interest to a subject in need thereof.
Dependencies are inferred from the claim text.