Long-acting EPO polypeptides and derivatives thereof and methods thereof
AssigneeModigene Inc
InventorsFuad Fares, Udi Eyal Fima
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Abstract
A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to an EPO peptide are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
Claims28
A polypeptide comprising an EPO peptide and at least two chorionic gonadotrophin carboxy terminal peptides, wherein a first chorionic gonadotrophin carboxy terminal peptide of said at least two chorionic gonadotrophin carboxy terminal peptides is attached to an amino terminus of said EPO peptide, and a second chorionic gonadotrophin carboxy terminal peptide of said at least two chorionic gonadotrophin carboxy terminal peptides is attached to a carboxy terminus of said EPO peptide.
A polynucleotide comprising a coding portion encoding a polypeptide, said polypeptide comprising an EPO peptide and at least two chorionic gonadotrophin carboxy terminal peptides, wherein a first chorionic gonadotrophin carboxy terminal peptide of said at least two chorionic gonadotrophin carboxy terminal peptides is attached to an amino terminus of said EPO peptide, and a second chorionic gonadotrophin carboxy terminal peptide of said at least two chorionic gonadotrophin carboxy terminal peptides is attached to the carboxy terminus of said EPO peptide.
A method of improving a biological half life of an EPO peptide, comprising the step of attaching a first chorionic gonadotrophin carboxy terminal peptide to an amino terminus of said EPO peptide and a second chorionic gonadotrophin carboxy terminal peptide to a carboxy terminus of said EPO peptide, thereby improving a biological half life of an EPO peptide.
A method of administering an EPO peptide to a subject in need thereof, comprising the step of attaching a first chorionic gonadotrophin carboxy terminal peptide to an amino terminus of said EPO peptide and a second chorionic gonadotrophin carboxy terminal peptide to a carboxy terminus of said EPO peptide, thereby generating an improved polypeptide for administration to said subject, thereby administering an EPO peptide to a subject in need thereof.
Dependencies are inferred from the claim text.