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US 2007/0190582 A1Published application
Platelet surface PF4 antigenic complexes as a diagnostic indicator in heparin-induced thrombocytopenia
OwnerMortimer Poncz, Douglas Cines +2inventors
InventorsMortimer Poncz, Douglas Cines, Gowthami Arepally, Lubica Rauova
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Abstract
A method for diagnosing a predisposition for developing HIT is provided.
Claims15
A method for diagnosing a patient's predisposition for the development of heparin-induced thrombocytopenia (HIT), comprising;
- a) obtaining a cell-containing biological sample from said patient;
- and
- b) determining the level of at least one of
- i) total platelet factor 4 (PF4 ) expression;
- ii) surface PF-4 expression;
- ii) expression of antigenic complexes comprising of PF4 and glycosaminoglycans on the surface of said cells,
- elevated levels of said PF4 or said antigenic complexes being indicative of a predisposition for the development of HIT.
4 more elements
A method for identifying agents useful for the treatment of heparin induced thrombocytopenia comprising;
- a) providing cells which express GAG-PF4 antigenic complexes on the surface;
- b) incubating said cells in the presence and absence of said agent;
- and
- c) identifying those agents which disrupt GAG-PF4 antigenic complexes, said agents having efficacy for the treatment of heparin induced thrombocytopenia, with the proviso that said agent is not heparin or protamine sulfate.
1 more element
Dependencies are inferred from the claim text.