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US 2007/0190577 A1Published application
Biologically active synthetic thyrotropin and cloned gene for producing same
OwnerFredric Wondisford, Bruce Weintraubinventors
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Abstract
Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH are described.
Claims18
Substantially pure, biologically active recombinant human thyrotropin (rTSH).
A kit comprising containers separately containing:
- (a) universal standard of substantially pure unlabeled rTSH;
- (b) substantially pure, labeled rTSH;
- (c) antibodies against purified rTSH;
- and
- (d) instructional material describing the use of reagents (a), (b) and (c).
2 more elements
Anti-rTSH antibodies without interfering cross-reactivity with non-TSH hormones.
A method for treating thyroid cancer, comprising administering therapeutic regimen of a combination of rTSH of claim 1 and 131I or 131I-labeled rTSH to a patient afflicted with thyroid cancer.
Dependencies are inferred from the claim text.