Mitogenic oxygenase regulators
AssigneeEmory University
InventorsJ. Lambeth, Guangjie Cheng
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Abstract
The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
Claims14
1-11. (canceled)
An isolated antibody, wherein the antibody specifically binds the amino acid sequence of SEQ ID NO:4, a fragment of SEQ ID NO:
- 4 capable of superoxide production or a substitution of SEQ ID NO:
- 4 of less than 1% of the amino acid sequence capable of superoxide production.
14-22. (canceled)
A method for detecting a protein, comprising
- contacting a sample with the antibody of claim 1;
- and
- detecting binding of the antibody to a protein comprising the amino acid sequence of SEQ ID NO:4, a fragment of SEQ ID NO:
- 4 capable of superoxide production or a substitution of SEQ ID NO:
- 4 of less than 1% of the amino acid sequence, wherein the isolated protein is capable of superoxide production,
- thereby detecting the protein.
Dependencies are inferred from the claim text.