Osteoactivin protein and nucleic acids encoding the same, compositions and methods of stimulating bone differentiation
AssigneeTemple University
InventorsSteven Popoff, Fayez Safadi, Thomas Owen, Steven Smock
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Abstract
The invention provides osteoactivin proteins and nucleic acid molecules that encode the same, as well as biologically functional expression vectors containing nucleic acid molecules encoding osteoactivin proteins, and antibodies specific for osteoactivin proteins. The invention also provides therapeutic and diagnostic compositions and methods for utilizing the proteins, antibodies, nucleic acids, and vectors of the invention, for example, to modulate bone formation.
Claims26
A nucleic acid molecule, wherein said nucleic acid molecule encodes a polypeptide comprising SEQ ID NO:2.
2-38. (canceled)
A method for stimulating bone formation in a mammal, comprising administering to a mammal a bone-stimulatory amount of a nucleic acid molecule encoding an osteoactivin protein, wherein the encoded osteoactivin protein stimulates bone differentiation or bone formation.
A method for stimulating bone formation in a mammal, comprising
- (a) extracting osteoblasts from a mammal;
- (b) introducing into said osteoblasts a nucleic acid encoding an osteoactivin protein;
- and
- (c) returning the osteoblasts of step (b) to said mammal, wherein the encoded osteoactivin protein stimulates bone differentiation or bone formation.
An osteoblast comprising a transgene encoding an osteoactivin protein.
Dependencies are inferred from the claim text.