Diagnostic method for identifying carriers of the Marburg I variant of factor VII-activating protease (FSAP) on the basis of differential modulation of FSAP activity
AssigneeDade Behring Marburg GmbH
InventorsFrank Vitzthum, Herbert Schwarz
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Abstract
The present invention relates to a diagnostic method for identifying persons with genetically related hetero- or homozygous expression of the MR I variant of factor VII-activating protease (FSAP). The heterozygous or homozygous presence of an MR I polymorphism can be identified by a differential modulation of the FSAP activity.
Claims18
1-10. (canceled)
A method for identifying individuals with heterozygous or homozygous expression of the Marburg I (MR I) variant of factor VII-activating protease (FSAP), comprising determining FSAP activity in the absence and in the presence of a differential activity modulator, wherein the differential activity modulator changes the FSAP activity in samples from individuals with heterozygous or homozygous expression of said MR I variant of FSAP to a different extent than the differential activity modulator changes the FSAP activity in samples from individuals who do not express said MR I variant of FSAP.
Dependencies are inferred from the claim text.