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US 2007/0190568 A1Published application
Method For Detecting at Least One Designated Genetic Sequence
AssigneeTransnetyx, Inc.
InventorTimothy Hodge
Life of this patent
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Abstract
The present invention provides a method to rapidly provide genotype screening of a plurality of biological samples in a designated well of a microwell container for remote user by a screening laboratory. The screening method can be used to determine if a biological sample is heterozygous, homozygous or wild for a designated genetic sequence.
Claims19
A method for detecting at least one designated genetic sequence in a biological sample comprising:
- a) treating said biological sample to obtain a lysate containing cellular debris including a genomic nucleic acid, wherein genomic said nucleic acid includes at least a portion of an intact nucleic acid;
- b) separating a standard concentration of genomic nucleic acid using magnetic particles;
- and
- c) screening said standard concentration of genomic nucleic acid to detect said designated genetic sequence.
1 more element
A method for detecting at least one designated genetic sequence in a biological sample comprising:
- a) treating said biological sample to obtain a lysate containing cellular debris including a genomic nucleic acid, wherein said genomic nucleic acid includes at least a portion of intact nucleic acid;
- b) separating said genomic nucleic acid using magnetic particles;
- c) adding at least one probe and primer set corresponding to one of said at least one designated genetic sequence to said biological sample in said at least one well of a microwell container;
- d) adding at least one probe and primer set corresponding to a reference sequence to said biological sample in said at least one well of a microwell container;
- e) screening said biological sample in said at least one well of a microwell container to obtain screening results, wherein one of said screening results is probe values;
- and
- f) comparing the probe values for said probe corresponding to said designated genetic sequence with said probe value corresponding to said reference sequence to detect said at least one designated genetic sequence.
4 more elements
Dependencies are inferred from the claim text.