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US 2007/0190561 A1Published application
Segments of the Human Gene for Telomerase Reverse Transcriptase
AssigneeGeron Corporation
InventorsGregg Morin, William Andrews
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Abstract
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
Claims20
An isolated polynucleotide from the gene for human telomerase reverse transcriptase (hTRT) comprising a sequence having at least one of the following features:
- a) it contains at least 25 consecutive nucleotides within SEQ. ID NO:6 but not within SEQ. ID NO:1.
- b) it is complementary to a);
- or
- c) it contains at least 25 consecutive nucleotides within the insert of Lambda phage GΦ5 (ATCC Accession No. 98505), but not within the insert of Lambda phage 25-1.1 (ATCC Accession No. 209024).
1 more element
Dependencies are inferred from the claim text.