Non-alloying core shell nanoparticles
AssigneeNanosphere, Inc.
InventorsChad Mirkin, Yun-Wei Cao, Rongchao Jin
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Abstract
The present invention relates composite core/shell nanoparticles and a two-step method for their preparation. The present invention further relates to biomolecule-core/shell nanoparticle conjugates and methods for their preparation. The invention also relates to methods of detection of biomolecules comprising the biomolecule-core/shell nanoparticle conjugates.
Claims38
An core/shell nanoparticle comprising:
- (a) an inner metal-containing nanoparticle core;
- and
- (b) an outer non-alloying gold shell surrounding the nanoparticle core.
A core/shell nanoparticle oligonucleotide conjugate comprising:
- (a) an inner metal-containing nanoparticle core;
- (b) an outer non-alloying gold shell surrounding the nanoparticle core;
- and
- (c) oligonucleotides attached to the gold shell.
A silver/gold core/shell nanoparticle comprising:
- (a) an inner silver nanoparticle core;
- and
- (b) an outer non-alloying gold shell surrounding the nanoparticle core.
A magnetic core/shell nanoparticle comprising:
- (a) an inner Fe3O4 nanoparticle core;
- and
- (b) an outer non-alloying gold shell surrounding the nanoparticle core.
A semiconductor core/shell nanoparticle comprising:
- (a) an inner semiconductor nanoparticle core;
- and
- (b) an outer non-alloying gold shell surrounding the nanoparticle core.
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Dependencies are inferred from the claim text.