Assay implementation in a microfluidic format
AssigneeHoneywell International Inc.
InventorsYuandong Gu, Aravind Padmanabhan
Life of this patent
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Abstract
An assay implementation in a microfluidic format in a cartridge relating to a point-of-care instrument platform for monitoring and diagnosing infectious diseases (e.g., AIDS and malaria). The platform may also provide a complete blood count. The instrument platform may hold the cartridge and a portion of an optical system for fluorescent and scattered light related analyses of blood sample in a flow channel of the cartridge.
Claims36
A point of care analyzer comprising:
- a portable instrument;
- and
- a microfluidic cartridge insertable in the instrument;
- and
- wherein:
- the instrument and cartridge comprise:
- a flow channel for conveying a blood sample;
- at least one fluorescent optical channel for detecting and identifying markers on constituents of the blood sample for an immunoassay;
- and
- at least one scattering optical channel for determining a count and/or properties of constituents of the blood sample;
- and
- the constituents of the blood sample to be detected in an immunoassay may be at least one of a group of CD4, CD45, CDX, CDXX, p. falciparum, p. vivax, various other pathogens, and the like.
A method for attaining a microfluidic-based assay on a cartridge, comprising:
- providing a sample of whole blood to a microfluidic cartridge;
- and
- performing a microfluidic-based assay on the cartridge situated in a portable instrument of an analyzer.
A point of care analyzer comprising:
- an immunoassay module;
- and
- a hematology module;
- and
- wherein at least portions of the modules are situated in a cartridge insertable in an instrument of the analyzer.
A method for blood analysis comprising:
- performing a hematology test;
- and
- performing a immunoassay;
- and
- wherein the test and assay are performed with a single microfluidic cartridge.
An assay system comprising:
- a card;
- and
- an immunoassay component situated in the card.
Dependencies are inferred from the claim text.