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US 2007/0190520 A1Published application
Method of characterizing a biologically active compound
OwnerDavid WOLF, Donnie RUDDinventors
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Abstract
A method of characterizing a biologically active compound by placing a cell mixture into a rotatable bioreactor to initiate a three-dimensional culture comprising a biological component and at least one cell, controllably expanding the cells in the rotatable bioreactor and testing the biological component to characterize the biologically active compound. The present invention may also preferably comprise exposing the cells to a time varying electromagnetic force.
Claims28
A method of characterizing a biologically active compound comprising:
- placing a cell mixture into a rotatable bioreactor to initiate a three-dimensional culture wherein the three-dimensional culture comprises cells and a biological component;
- controllably expanding the cells in the three-dimensional culture while at the same time maintaining the cells three dimensional geometry and cell-to-cell support and geometry by rotating the rotatable bioreactor;
- introducing a biologically active compound to the three dimensional culture;
- and
- testing the biological component using a test to characterize the pharmaceutical compound.
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Dependencies are inferred from the claim text.