Medical adhesive and methods of tissue adhesion
OwnerEric Beckman, Jianying Zhanginventors
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Abstract
A method of adhering biological tissue that includes applying a bio-degradable adhesive to the tissue. The adhesive includes a moisture-curable, isocyanate-functional component prepared by reacting (a) a multi-functional isocyanate component and (b) a multi-functional active hydrogen component that includes at least 30% by weight, based upon the total weight of the multi-functional active hydrogen component, of a multi-functional active hydrogen reactant having an equivalent weight less than 100. The ratio R of active hydrogen groups to isocyanate groups can be less than 1.0.
Claims32
A method of adhering biological tissue comprising applying a bio-degradable adhesive to the tissue,
- the adhesive comprising a moisture-curable, isocyanate-functional component prepared by reacting:
- (a) a multi-functional isocyanate component;
- and
- (b) a multi-functional active hydrogen component comprising at least 30% by weight, based upon the total weight of the multi-functional active hydrogen component, of a multi-functional active hydrogen reactant having an equivalent weight less than 100.
An adhesive comprising a moisture-curable, isocyanate-functional component prepared by reacting:
- (a) a multi-functional isocyanate component having an average functionality of 2;
- and
- (b) a multi-functional active hydrogen component having an average functionality of at least 3 that includes at least 30% by weight, based upon the total weight of the multi-functional active hydrogen component, of a multi-functional active hydrogen reactant having an equivalent weight less than 100,
- wherein:
- (i) the ratio R of active hydrogen groups to isocyanate groups is selected such that 0.5<R<0.9,
- (ii) the multi-functional active hydrogen component is free of multi-functional active hydrogen reactants having main chain ether or ester linkages, and
- (iii) the adhesive is bio-degradable and suitable for application to biological tissue.
An adhesive comprising a moisture-curable, isocyanate-functional component prepared by reacting:
- (a) a multi-functional isocyanate component having an average functionality of 3;
- and
- (b) a multi-functional active hydrogen component having an average functionality of at least 2 that includes at least 30% by weight, based upon the total weight of the multi-functional active hydrogen component, of a multi-functional active hydrogen reactant having an equivalent weight less than 100,
- wherein:
- (i) the ratio R of active hydrogen groups to isocyanate groups is selected such that 0.33<R<0.9,
- (ii) the multi-functional active hydrogen component is free of multi-functional active hydrogen reactants having main chain ether or ester linkages, and
- (iii) the adhesive is biodegradable and suitable for application to biological tissue.
A biodegradable moisture-curable, isocyanate-functional composition comprising:
- (A) the reaction product of:
- (a) a multi-functional isocyanate component;
- and
- (b) a multi-functional active hydrogen component comprising at least 30% by weight, based upon the total weight of the multi-functional active hydrogen component, of a multi-functional active hydrogen reactant having an equivalent weight less than 100, and
- (B) an agent selected from the group consisting of catalysts, latent hardening agents, rheology modifying agents, and combinations thereof.
A composition prepared by reacting:
- (a) a multi-functional isocyanate component having an average functionality of h;
- and
- (b) a multi-functional active hydrogen component having an average functionality of at least f and consisting essentially of multi-functional active hydrogen reactants having an equivalent weight less than 100,
- wherein a ratio R of active hydrogen groups to isocyanate groups is selected such that 1/h<R<0.9.
Dependencies are inferred from the claim text.