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US 2007/0190178 A1Published application
Composition and method for the therapeutic modulation of matrix metalloproteinase
OwnerStephen Monroe, Hans Hoekstrainventors
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Abstract
A synthesized composition containing one or more of zinc ions, calcium-ions, rubidium ions and/or potassium ions in a pharmaceutically acceptable carrier, which, when administered to a patient in need thereof, effectively modulates the activity of at least MMP-2 and/or MMP-9 in the wound. A method is disclosed.
Claims15
A method for therapeutic modulation of one or more matrix metalloproteinases (MMPS), comprising the steps of:
- identifying an elevated level of one or more MMPs expressed in tissue;
- administering a composition to the tissue to modulate the expression of one or more MMPs, wherein said composition comprises a pharmaceutically effective amount of a combination of zinc and rubidium ions in a physiologically inert carrier;
- monitoring the demodulation of the one or more MMPs in the tissue;
- and
- re-administering the composition to the tissue until the one or more MMP levels return near zero.
2 more elements
A method for therapeutic modulation of a matrix metalloproteinase (MMP), comprising the steps of:
- identifying an elevated level of MMP-2 or MMP-9 expressed in tissue;
- administering a composition to the tissue to modulate the expression of MMP-2 or MMP-9, wherein said composition comprises a pharmaceutically effective amount of a combination of zinc and rubidium ions in a physiologically inert carrier;
- monitoring the demodulation of the MMP-2 or MMP-9 in the tissue;
- and
- re-administering the composition to the tissue until MMP levels return near zero.
2 more elements
Dependencies are inferred from the claim text.