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US 2007/0190163 A1Published application
Technology for preparation of macromolecular microspheres
OwnerMichael Malaknov, Fang Fanginventors
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Abstract
Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.
Claims141
A method of making a protein-based composition, comprising:
- a) adding a counterion to a solution containing the protein in an aqueous solvent;
- b) adding an organic solvent to the solution;
- and
- c) gradually cooling the solution to a temperature below about 25° C., whereby a composition containing microparticles comprising the protein is formed, wherein steps a), b) and c) are performed simultaneously, sequentially, intermittently, or in any order.
1 more element
A composition, comprising microparticles of a sialidase or a sialidase fusion protein.
Dependencies are inferred from the claim text.