Molecular programming of nanoparticle systems for an ordered and controlled sequence of events for gene-drug delivery

A multi-functional and multi-step nanodelivery system having one or more nanoparticles, the nanoparticles comprising:

• a. one or more targeting molecules adapted to target the nanoparticle to one or more cells;
• and
• b. one or more cellular entry facilitating molecules coupled to the targeting molecules;
• the nanoparticle being adapted to manufacture quantities of the desired drug or gene from an intracellular location of the cell using one or more intracellular native components.

A multi-functional and multi-step nanodelivery system having one or more nanoparticles, the nanoparticles comprising:

• a. one or more targeting molecules adapted to target the nanoparticle to one or more cells;
• and
• b. one or more cellular entry facilitating molecules coupled to the targeting molecules;
• and
• c. one or more anchoring molecules coupled to the entry facilitating molecules and adapted to locate at least one nanoparticle at an intracellular selected site for subsequent intracellular drug or gene delivery.

A process for producing a multi-functional and multi-step nanodelivery system, acting in an autonomous controlled sequence of events at the molecular level, comprising:

• a. obtaining a nanoparticle;
• b. coupling a drug or gene to the nanoparticle;
• c. coupling a molecular biosensor to the drug or gene;
• and
• d. coupling a cell targeting molecule to the molecular biosensor.