Delivery systems for non-steroidal anti-inflammatory drugs (nsaids)
OwnerJonathan Farberinventor
Life of this patent
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Abstract
Oral gel delivery systems for non-steroidal anti-inflammatory drugs (NSAIDs) are provided comprising an ingestible matrix within which one or more NSAIDs are substantially uniformly and completely dispersed. The delivery systems may optionally include one or more other functional ingredients that complement or enhance the function of the NSAID(s) within the body.
Claims45
An oral gel delivery system for non-steroidal anti-inflammatory drugs (NSAIDs) comprising one or more NSAIDs substantially uniformly dispersed in a gel matrix, said delivery system having a final moisture content of between about 10% and about 40% by weight and a water activity of less than about 0.9, and said gel matrix comprising:
- a) one or more hydrocolloids;
- b) one or more sugars, sugar syrups, sugar alcohols, or a combination thereof;
- and
- c) one or more polyhydric alcohols.
An oral gel delivery system for non-steroidal anti-inflammatory drugs (NSAIDs) comprising one or more NSAIDs substantially uniformly dispersed in a gel matrix, said delivery system having a final moisture content of between about 10% and about 30% by weight and a water activity of less than about 0.7, and said gel matrix comprising:
- a) one or more hydrocolloids selected from the group of:
- modified starch, gelatine, gellan, pectin, cellulose and modified cellulose;
- b) one or more sugar syrups selected from the group of:
- corn syrup, high fructose corn syrup, maltitol syrup and isomalt syrup, and
- c) one or more polyhydric alcohols selected from the group of:
- glycerol and propylene glycol.
Use of a gel matrix comprising:
- a) one or more hydrocolloids;
- b) one or more sugars, sugar syrups, sugar alcohols, or a combination thereof, and
- c) one or more polyhydric alcohols, in the preparation of an oral gel delivery system for non-steroidal anti-inflammatory drugs (NSAIDs), wherein said delivery system comprises one or more NSAIDs substantially uniformly dispersed in said gel matrix, and said delivery system has a final moisture content of between about 10% and about 40% by weight and a water activity of less than about 0.9.
A process for preparing an oral gel delivery system for non-steroidal anti-inflammatory drugs (NSAIDs), said process comprising the steps of:
- (i) preparing a blend of one or more hydrocolloids, one or more sugars, sugar syrups, sugar alcohols, or a combination thereof, and optionally water at a temperature of less than 100° C., wherein said hydrocolloid(s), said sugars, sugar syrups and/or sugar alcohols and said water are in a ratio that will provide a final moisture content to the delivery system of between about 10% and about 40% by weight;
- (ii) reducing the temperature of said blend to between about 50° C. and about 80° C.;
- (iii) dispersing one or more NSAIDs in a solvent comprising one or more polyhydric alcohols at a temperature at or below about 70° C. to provide a solvent mixture;
- (iv) combining said blend from step (ii) with said solvent mixture to provide a gel matrix, and
- (v) moulding said gel matrix to provide said oral gel delivery system.
Dependencies are inferred from the claim text.