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US 2007/0190144 A1Published application
Multilayer tablet
AssigneeIntelgenx Corp.
InventorsHorst Zerbe, Nadine Paiement, Pompilia Ispas-Szabo
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Abstract
A multilayer oral dosage form that provides controlled release of an active compound includes a non-erodible core containing a pharmaceutically active compound and/or a nutritionally active compound, and at least one release-modulating layer laminated to each side of the core layer. The dosage form can be prepared using simple, inexpensive tablet compression techniques.
Claims20
A trilayer tablet, comprising:
- a non-erodible core layer containing at least one pharmaceutically active compound and/or at least one nutritionally active compound;
- and
- at least one erodible layer laminated to each side of the non-erodible core layer.
A method of making a controlled release trilayer oral dosage form comprising:
- combining at least one pharmaceutically active compound and/or at least one nutritionally active compound with one or more polymers capable of forming a non-erodible core layer upon compression to form a core mixture, the resulting core combination optionally including at least one excipient and/or at least one adjuvant;
- preparing a release-regulating powder comprising at least one polymer selected from swellable erodible polymers, insoluble erodible polymers, and water permeable erodible polymers;
- and
- forming a compressed tablet having a core layer consisting of compressed core mixture and a release-regulating layer laminated to each side of the core layer, the release-regulating layer consisting of compressed release-regulating powder.
1 more element
Dependencies are inferred from the claim text.