Dosage forms having a microreliefed surface and methods and apparatus for their production
OwnerFrank Bunick, Jen-Chi Cheninventors
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Abstract
The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of counterfeit production thereof, wherein the edible dosage forms may be made in a variety of ways to incorporate the optical elements therein.
Claims38
A process for producing a microrelief on a dosage form having a core, said process comprising:
- applying the microrelief to the core by way of compression, wherein the core is comprised of a powder blend containing a plastically deforming compressible material.
A process for producing a diffraction grating microrelief on a dosage form having a core, said core having a core surface, comprised of:
- a) applying the microrelief to the core surface during compression;
- and
- b) applying a top coat layer to at least the portion of the core surface bearing the microrelief, said top coat layer having an inner surface proximate to the core, wherein the core is comprised of an active ingredient, a plastically deforming compressible material, and an absorbent excipient.
A pharmaceutical tablet comprising:
- a core containing at least one active ingredient and at least one excipient, and having a first face surface and an opposed second face surface,
- wherein at least one of the excipients or the active ingredients is in the form of compressed particles having a diameter from about 50 microns to about 500 microns, and
- wherein at least one of said first face surface or said second face surface bears a microrelief.
A pharmaceutical dosage form comprising:
- a tablet core containing at least one active ingredient and at least one excipient, said tablet core having an outer core surface, and
- a top coat layer covering at least a portion of the outer core surface, said top coat layer having an interior surface proximate to said outer core surface, said interior surface bearing a microrelief,
- wherein at least one of the excipients or active ingredients is in the form of compressed particles having a diameter from about 50 microns to about 500 microns.
Dependencies are inferred from the claim text.