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US 2007/0190128 A1Published application
Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds
AssigneeSigma-Tau Industrie Farmaceutiche Riunite S.p.A.
InventorsClaudio Pisano, Maria Tinti, Mose Santaniello, Luciana Critelli, Giovanni Salvatori
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Abstract
Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
Claims10
-53. (canceled)
A method of transporting a naturally occurring or modified plasmid or polynucleotide using a lipsome containing a compound of formula (III):
- where:
- R5 is selected from the group consisting of nonanoyl, dodecanoyl, myristoyl, palmitoyl, stearoyl or oleoyl;
- R6 is selected from the group consisting of nonyl, undecyl, tetradecyl, hexadecyl or oleyl;
- and
- X− is the anion of a pharmacologically acceptable acid.
2 more elements
Dependencies are inferred from the claim text.