Non-Absorbent Articles Containing Additives for Inhibiting the Production of TSST-1
AssigneeKimberly-Clark Worldwide, Inc.
InventorsRae Syverson, Richard Proctor
Life of this patent
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Abstract
Non-absorbent articles, such as tampon applicators, containing an additive are disclosed. The non-absorbent articles include an effective amount of an inhibitory compound, such as thiolactomycin or thiomalonate, for example, to substantially inhibit the production of TSST-1 or exoprotein by Gram positive bacteria.
Claims20
A tampon applicator comprising a non-absorbent substrate, an effective amount of a first active ingredient and an effective amount of a second active ingredient, the first active ingredient having a general formula:
- wherein:
- R300 is, when present, selected from hydrogen and substituted or unsubstituted alkyl;
- R301 is selected from the group consisting of hydrogen, a monovalent, saturated or unsaturated, substituted or unsubstituted hydrocarbyl moiety, and when R300 is not present, a substituted or unsubstituted hydrocarbenyl moiety;
- R302 is selected from hydrogen, substituted or unsubstituted alkyl;
- and, R303 is selected from hydrogen, hydroxy, and alkoxy, the second active ingredient having a general formula:
- R10—O—R11 (IV)
- wherein R10 is a straight or branched alkyl or straight or branched alkenyl having from 8 to about 18 carbon atoms and R11 is selected from the group consisting of an alcohol, a polyalkoxylated sulfate salt and a polyalkoxylated sulfosuccinate salt, and wherein the first active ingredient and the second active ingredient are effective in substantially inhibiting the production of TSST-1 from Gram positive bacteria.
A non-absorbent article comprising a non-absorbent substrate, an effective amount of a first active ingredient, and an effective amount of a second active ingredient, the first active ingredient having a general formula:
- wherein:
- R300 is, when present, selected from hydrogen and substituted or unsubstituted alkyl;
- R301 is selected from the group consisting of hydrogen, a monovalent, saturated or unsaturated, substituted or unsubstituted hydrocarbyl moiety, and when R300 is not present, a substituted or unsubstituted hydrocarbenyl moiety;
- R302 is selected from hydrogen, substituted or unsubstituted alkyl;
- and, R303 is selected from hydrogen, hydroxy, and alkoxy, the second active ingredient having a general formula:
- R10—O—R11 (IV)
- wherein R10 is a straight or branched alkyl or straight or branched alkenyl having from 8 to about 18 carbon atoms and R11 is selected from the group consisting of an alcohol, a polyalkoxylated sulfate salt and a polyalkoxylated sulfosuccinate salt, wherein the first active ingredient and the second active ingredient are effective in substantially inhibiting the production of TSST-1 from Gram positive bacteria, and wherein the non-absorbent article is selected from the group consisting of non-absorbent incontinence devices, barrier birth control devices, and douches.
Dependencies are inferred from the claim text.