Flowable bone grafts
OwnerChunlin Yang, Jacky Au-Yeung +6inventors
InventorsChunlin Yang, Jacky Au-Yeung, Iksoo Chun, Mark Davis, Lu Liu, Aruna Nathan, Vivek Shenoy, Mark Timmer
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Abstract
The present invention is directed to bone graft compositions suitable for administration to the body via a cannula, where the compositions contain mineralized collagen particles and a fluid biocompatible carrier having the mineralized collagen particles substantially uniformly distributed there through, which particles contain bound mineralized collagen fibrils substantially uniformly distributed there through and a binder for the fibrils; and to methods of making such particles.
Claims23
A bone graft composition suitable for administration to the body via a cannula, comprising:
- mineralized collagen particles comprising bound mineralized collagen fibrils substantially uniformly distributed there through and a binder for said fibrils;
- and
- a fluid biocompatible carrier comprising said mineralized collagen particles substantially uniformly distributed there through.
The composition of claim 8 wherein said bioactive agent comprises human bone marrow.
A method for the preparation of mineralized collagen particles, comprising:
- preparing an aqueous solution of a water-soluble material suitable for use as a binder for mineralized collagen fibrils,
- combining said mineralized collagen fibrils with said solution under conditions effective to prepare a homogenous aqueous slurry comprising said fibrils and said solution,
- combining said slurry with an oil phase to form an emulsion of said slurry in said oil phase,
- mixing said emulsion to form mineralized collagen particles comprising said binder material,
- crosslinking said mineralized collagen particles comprising said binder material;
- and
- isolating said crosslinked mineralized collagen particles from said emulsion, whereby said mineralized collagen particle comprises said mineralized collagen fibrils bound and substantially uniformly distributed there through.
Dependencies are inferred from the claim text.