Methods for the selective modulation of ppar
AssigneeKalypsys, Inc.
InventorsAndrew Shiau, Mark Massari, Guy Oshiro, Ayman Kabakibi, James Malecha, Stewart Noble
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods of selective modulation of peroxisome proliferator activated receptors (PPARs) over G-protein coupled receptor 40 (GPR40), and the use of therapeutically effective amounts of compounds and pharmaceutical compositions which selectively modulate PPAR over GPR40 for the treatment of diseases in patients in need thereof. The methods disclosed herein are exceptionally useful in treating metabolic diseases whilst avoiding certain side effects common to modulators of PPAR previously disclosed in the art.
Claims42
A method of treating a PPAR-mediated disease in a patient in need thereof comprising selectively modulating PPAR over GPR40.
A method of reducing or eliminating one or more side effects associated with a modulator of PPAR, comprising selectively modulating PPAR over GPR40.
A method of increasing HDLs (high-density lipoproteins) or HDL-C (high density lipoprotein cholesterol) without causing a hypoglycemic state comprising selectively modulating PPAR over GPR40.
A method of reducing triglycerides without causing a hypoglycemic state comprising selectively modulating PPAR over GPR40.
A method of reducing visceral fat in a patient in need thereof, comprising selectively modulating PPAR over GPR40.
A method of reducing insulin resistance in a patient in need thereof, comprising selectively modulating PPAR over GPR40.
A method of enhancing glucose utilization in a patient in need thereof, comprising selectively modulating PPAR over GPR40.
Dependencies are inferred from the claim text.