Anti-HIV agents
OwnerManabu Wada, Naoko Wadainventors
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Abstract
Anti-HIV agents are disclosed. The agents comprise as the active component one of ligand molecules that bind to CD87. Examples of such ligand molecules included the high molecular weight urokinase-type plasminogen activator, its amino-terminal fragment, their analogues and anti-CD87 antibodies.
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A method for treating an HIV-infected human for suppression of reproduction of HIV in the human comprising administering to the human an HIV reproduction-suppressive amount of a ligand molecule binding to CD87.
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A method for treating an HIV-1-infected human for suppression of reproduction of HIV-1 in the human comprising:
- injecting the human with an HIV-1 reproduction-suppressive amount of an anti-HIV-1 pharmaceutical composition for injection comprising an amino-terminal fragment of the high molecular weight urokinase-type plasminogen activator (HMW-uPA) as an active component, the fragment being contained in a sterile aqueous or non-aqueous medium, wherein the fragment comprises amino acids 21-155 of the prepro-urokinase (sc-uPA) and does not extend beyond amino acid 178 of the sc-uPA.
A method for treating an HIV-1-infected human for suppression of reproduction of HIV-1 in the human comprising injecting the human with an HIV-1 reproduction-suppressive amount of an anti-HIV-1 pharmaceutical composition for injection comprising an amino-terminal fragment of the high molecular weight urokinase-type plasminogen activator (HMW-uPA) as an active component, the fragment being contained in a sterile aqueous or non-aqueous medium, wherein the fragment contains an EGF-like domain, a Kringle domain and a urokinase receptor binding domain of the high molecular weight urokinase-type plasminogen activator (HMW-uPA) and no portion of the B-chain of the HMW-uPA.
A method for treating an HIV-1-infected human for suppression of reproduction of HIV-1 in the human comprising:
- transnasally or transpulmonarily applying to the human an anti-HIV-1 pharmaceutical composition for transnasal or transpulmonary application in the form of a dry powder consisting of an amino-terminal fragment of the high molecular weight urokinase-type plasminogen activator (HMW-uPA) as an active component and a carrier, wherein the fragment comprises amino acids 21-155 of the prepro-urokinase (sc-uPA) and does not extend beyond the amino acid 178 of the sc-uPA.
A method for treating an HIV-1-infected human for suppression of reproduction of HIV-1 in the human comprising:
- transnasally or transpulmonarily applying to the human an anti-HIV-1 pharmaceutical composition for transnasal or transpulmonary application in the form of a dry powder consisting of an amino-terminal fragment of the high molecular weight urokinase-type plasminogen activator (HMW-uPA) as an active component and a carrier, wherein the fragment contains an EGF-like domain, a Kringle domain and a urokinase receptor binding domain of the high molecular weight urokinase-type plasminogen activator (HMW-uPA) and no portion of the B-chain of the HMW-uPA.
Dependencies are inferred from the claim text.