Gram positive bacteria preparations for the treatment of disease comprising an immune dysregulation
AssigneeInstitut Pasteur and Institut National de la Sante et de la Recherche Medicale
InventorsMarie-Anne Nahori, Micheline Lagranderie, Gilles Marchal, Bernado Vargaftig, Jean Lefort, Felix Romain, Georges Hekimian, Philippe Peltre
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Abstract
Compositions comprising components prepared from Gram positive bacteria such as Gram positive facultative intra-cellular bacteria, for example mycobacteria, including extended freeze-dried killed Gram positive bacteria, their method of preparation and their use in humans and animals, for the prevention and/or the treatment of disorders comprising an immune dysregulation such as cancer, autoimmune diseases, allergy and tuberculosis.
Claims26
1) A bacterial preparation, characterized in that:
- it contains killed Gram positive bacteria, obtainable by a process which does not denature the structure of the molecules from the bacteria cells, and
- it is able to induce, in vivo, a modulation of the immune response against an antigen.
Dependencies are inferred from the claim text.