Antibody-mediated enhancement of immune response
OwnerKeith Bahjat, Dirk Brockstedt +1inventors
InventorsKeith Bahjat, Dirk Brockstedt, William Greenman
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Abstract
Provided are reagents and methods for administering an attenuated bacterium and a binding compound for treating a cancerous or infectious condition, where the binding compound comprises an antibody or an antigen binding site derived from an antibody.
Claims63
A method for stimulating an immune response against a cancerous or infectious condition in a mammal having the condition, comprising administering to the mammal effective amounts of a Listeria and:
- a. an antibody that specifically binds to an antigen of the condition;
- or
- b. a binding compound derived from the antigen-binding site of an antibody that specifically binds to an antigen of the condition and also specifically binds to an immune cell that mediates antibody-dependent cell cytotoxicity (ADCC),
- wherein the combination of the Listeria and the antibody, or binding compound, is effective in stimulating the response.
A method for treating a cancerous or infectious condition in a mammal having the condition, comprising administering to the mammal effective amounts of a Listeria with:
- a. an antibody that specifically binds to an antigen of the condition;
- or
- b. a binding compound derived from an antibody that specifically binds to an antigen of the condition and also specifically binds to an immune cell that mediates ADCC,
- wherein the combination of the Listeria and the antibody, or binding compound, is effective in ameliorating or reducing the condition.
Dependencies are inferred from the claim text.