Antithrombotic agents
AssigneeSmithKline Beecham Corporation
InventorsFrank Barone, Michael Blackburn, Giora Feuerstein, John Toomey
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Abstract
Monoclonal antibodies directed against coagulation factor IX and their use in inhibiting thrombosis are disclosed.
Claims23
A method for treating an animal post-thromboembolic induced ischemia comprising administering an anti-Factor IX antibody or antibody fragment.
A method for treating an animal post-thromboembolic induced ischemia comprising administering SB 249417.
A method for treating an animal post-thromboembolic induced ischemia comprising administering an anti-Factor IX antibody or antibody fragment in combination with a plasminogen activator.
A method for treating an animal post-thromboembolic induced ischemia comprising administering SB 249417 in combination with tPA.
A method for reducing a required dose of a thrombolytic agent in treatment of an animal post-thromboembolic induced ischemia comprising administering an anti-Factor IX antibody or antibody fragment in combination with the thrombolytic agent.
A method for preventing thromboembolic stroke in an animal comprising administering an anti-Factor IX antibody or antibody fragment to an animal at risk for thromboembolic stroke.
A method of preventing thromboembolic stroke in an animal comprising administering SB 249417 to an animal at risk for thromboembolic stroke.
Dependencies are inferred from the claim text.