Regulatory CD8cells induced with anti-CD3 antibody
AssigneeThe Trustees of Columbia University in the City of New York
InventorsKevan Herold, Jeffrey Bluestone, Brygida Bisikirska
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Abstract
The invention provides methods for treating autoimmunity, for reestablishing tolerance, and for generally dampening or suppressing the activation state of the immune system. The methods involve the induction or activation of a particular regulatory T cell population, characterized by its expression of CD8, CD25 and Foxp3.
Claims20
A method for inhibiting a CD4+ T cell, the method comprising contacting the CD4+ T cell with a regulatory T cell that at least expresses CD8, CD25 and Foxp3.
A method for regulating the immune system in a subject, the method comprising administering to the subject a weak TCR agonist such that the TCR agonist expands the population of T cells that express CD8, CD25 and Foxp3.
A method for regulating the immune system in a subject, the method comprising administering to the subject a T cell that expresses CD8, CD25 and Foxp3.
A method for regulating the immune system in a subject or for restoring or establishing tolerance in the subject, the method comprising:
- (a) isolating a cell population or sample from the subject;
- (b) contacting the cell population with a weak TCR agonist;
- (c) separating from the cell population a T cell that expresses CD8, CD25, and Foxp3;
- and
- (d) administering to the subject the T cell that expresses CD8, CD25, and Foxp3.
A method for regulating the immune system in a subject or for restoring or establishing tolerance in the subject, the method comprising:
- (a) administering to the subject a weak TCR agonist;
- (b) isolating a cell population or sample from the subject;
- (c) contacting the cell population with the weak TCR agonist;
- (d) separating from the cell population a T cell that expresses CD8, CD25, and Foxp3;
- and
- (e) administering to the subject the T cell that expresses CD8, CD25, and Foxp3.
Dependencies are inferred from the claim text.