Back to results
US 2007/0190040 A1Published application
Recombinant p53 adenovirus methods and compositions
OwnerWei-Wei Zhang, Jack Rothinventors
Life of this patent
Estimating the term…
Abstract
Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct. observation of a cytopathic effect (CPE) in the transfected cells. Also disclosed are compositions and methods involving novel p53 adenovirus constructs, including methods for restoring p53 function and tumor suppression in cells and animals having abnormal p53.
Claims16
1-21. (canceled)
A pharmaceutical composition comprising a pharmacologically acceptable solution or buffer and a replication-deficient adenovirus comprising a nucleic acid sequence encoding
- i) wild-type human p53 under the control of a promoter;
- and
- ii) a polyadenylation signal,
- wherein the nucleic acid sequence replaces the E1 A and E1 B regions and the adenovirus comprises adenovirus serotype 5 sequence.
1 more element
Dependencies are inferred from the claim text.