Back to results
US 2007/0190036 A1Published application
Microencapsulation of pancreatic islets within a thin coat of glucagon-like peptide-1 functionalized poly(ethylene glycol)
OwnerSeda Kizilel, Jason Wyman +3inventors
InventorsSeda Kizilel, Jason Wyman, Milan Mrksich, Sidney Nagel, Marc Garfinkel
Life of this patent
Estimating the term…
Abstract
Microencapsulation of pancreatic islets within a thin poly(ethylene glycol) (PEG) coat is provided. The PEG coat is functionalized with an insulinotropic agent, glucagon-like peptide 1 (GLP-1). The encapsulated pancreatic islets may be used for the treatment of type I diabetes.
Claims22
A functionalized coating for encapsulating pancreatic islets comprising:
- a thin poly(ethylene glycol) (PEG) hydrogel adapted to coat pancreatic islets, the PEG hydrogel having crosslinked networks of PEG diacrylate;
- and
- an insulinotropic agent incorporated into the crosslinked networks of the PEG diacrylate.
Prepared tissue for implantation into a patient comprising:
- donor tissue;
- and
- a coating encapsulating the donor tissue, the coating functionalized with glucagon-like-peptide-1 (GLP-1).
A method of coating biological material for implantation into a patient comprising:
- creating a precursor solution that includes a peptide;
- adding the biological material to the pre-polymer solution;
- encapsulating the biological material by selectively withdrawing the biological material within the precursor solution;
- photocrosslinking the precursor solution encapsulated biological material to form a crosslinked hydrogel network incorporating the peptide.
1 more element
Dependencies are inferred from the claim text.