Diabetes Treatment Methods and Drug Targets Therefor
AssigneeThe Regents of the University of California
InventorsKenneth Chien, Lisa Lesniewski, Jerrold Olefsky, Mohammad Pashmforuoush
Life of this patent
Estimating the term…
Abstract
Provided are methods of treating insulin resistance or type II diabetes. Disrupting CAP in the macrophage can alter the inflammatory response associated with impaired insulin action and ultimately result in improved insulin action in target tissues. One aspect of the invention involves administering a CAP antagonist to a patient afflicted with insulin resistance or type II diabetes in an amount sufficient to improve insulin action in target tissues.
Claims20
A method of treating a disease or disorder involving insulin metabolism in a subject, the method comprising:
- a) providing an in vitro cell culture comprising macrophages having reduced CAP activity in comparison to macrophages comprised by a subject in need of treatment;
- and
- b) administering cells comprised by the in vitro cell culture to the subject.
An in vitro cell culture comprising macrophages having reduced CAP activity in comparison to macrophages comprised by a subject in need of treatment.
Dependencies are inferred from the claim text.