Bacteriophage-containing therapeutic agents

A method of therapeutic or prophylactic treatment of a bacterial infection characterized by biofilm formation which comprises administering to a human or non-human animal in need thereof one or more bacteriophages capable of targeting bacteria of said infection and simultaneously, separately or sequentially thereto one or more antibiotics

A bacteriophage selected from the bacteriophage strains NCIMB 41174, NCIMB 41175, NCIMB 41176, NCIMB 41177, NCIMB 41178, NCIMB 41179, NCIMB 41180 and NCIMB 41181 deposited at the National Collection of Industrial and Marine Bacteria, Aberdeen, United Kingdom, or mutants thereof which retain the ability to target P. aeruginosa.

A combined product for simultaneous, separate or sequential administration of a panel of bacteriophages to treat a bacterial infection comprising or consisting of Pseudomonas aeruginosa, each member of said panel having a different strain specificity and wherein said panel consists of two or more bacteriophages selected from NCIMB 41174, NCIMB 41175, NCIMB 41176, NCIMB 41177, NCIMB 41178, NCIMB 41179, NCIMB 41180, NCIMB 41181 and mutants thereof which retain the ability to target P. aeruginosa.

A non-therapeutic method of removing, reducing or preventing bacterial contamination characterized by biofilm formation, said method comprising applying to the site or prospective site of said contamination one or more bacteriophages capable of targeting bacteria of said contamination and simultaneously, separately or sequentially thereto one or more antibiotics or antiseptics

A method of identifying a bacterial strain selective for one of the bacteriophages NCIMB 41174, NCIMB 41175, NCIMB 41176, NCIMB 41177, NCIMB 41178, NCIMB 41179, NCIMB 41180 and NCIMB 41181, the method comprising the steps of measuring plaque formation by said bacteriophage in a number of bacterial strains and selecting a strain which allows at least 1000 times more plaque formation by said bacteriophage than by any of said other bacteriophages.