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AssigneeMount Sinai School of Medicine
InventorsMichela Battista, Paul Frenette, Wei-Ming Kao
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Methods and compositions for modulating the mobilization of stem cells, particularly for promoting or increasing the mobilization of hematopoietic stem cells from the bone marrow to the peripheral blood are disclosed. In particular, the invention relates to the use of adrenergic agonists that act in concert with a mobilization compound or agent. The mobilization agent(s) may act to decrease the expression or function of the chemokine, CXCL12, or may act to block or antagonize CXCR4. The invention also relates to methods of using these compounds or agents for enhancing the mobilization of hematopoietic stem cells when harvesting of the stem cells is necessary for the treatment of diseases, disabilities or conditions whereby transplantation of such cells would be beneficial in ameliorating the symptoms associated with such diseases, disabilities or conditions. Methods of screening for novel agents and pharmaceutical compositions comprising these agents are also disclosed.
A method of increasing or promoting the mobilization of hematopoietic stem cells or progenitor cells from the bone marrow to the peripheral blood of a mammal, the method comprising administering to the mammal a therapeutically effective amount of an adrenergic receptor agonist and a mobilizer of hematopoietic stem cells or progenitor cells.
A method for obtaining a population of hematopoietic stem cells or progenitor cells from a subject, the method comprising the steps of:
A pharmaceutical composition comprising an adrenergic receptor agonist and a mobilizer of hematopoietic stem cells or progenitor cells and a pharmaceutically acceptable carrier.
A method of preventing the migration of a stem cell from its niche in a tissue, or for retaining the stem cell within its niche in the tissue, the method comprising treating a subject with an effective amount of an adrenergic receptor antagonist.
A method of inhibiting the growth, proliferation, and/or metastasis of a tumor cell, comprising administering to a mammal an effective amount of an adrenergic receptor agonist, a mobilizer of stem cells and a therapeutically effective amount of either an anti-cancer agent/drug, or an amount of radiotherapy effective to inhibit growth, proliferation and/or metastasis of the tumor cell.
A method of enhancing the migration of a cancer stem cell from its niche or microenvironment within a tissue of a subject to the circulatory or lymphatic system, or to another tissue or organ, the method comprising administering an effective amount of an adrenergic receptor agonist and a stem cell mobilizer to the subject, wherein the method results in progression of the cancer stem cell from a quiescent state within the microenvironment to a proliferative state.
A method of screening in vitro for agents that promote mobilization of hematopoietic stem cells or progenitor cells, the method comprising the steps of:
Dependencies are inferred from the claim text.