Animal model for HIV induced disease
OwnerNelson M. Karpinventor
Life of this patent
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Abstract
HIV does not cause disease in any non-human species. Thus, there is no animal model system to evaluate the efficacy of strategies aimed at preventing, treating or curing disease caused by this virus. The present invention provides compositions and a method for producing an animal model for HIV induced disease. The present invention is an animal adapted to simulate a human-like immune response to HIV, which is accomplished by activation and inactivation of complement of proteins within the animal. Accordingly, the present invention stages certain human proteins within an animal by way of its gut associated lymphoid tissue followed by infection of live HIV.
Claims38
A method for the production of an animal model for HIV comprising the steps of:
- a. creating and administering HIV related proteins necessary for HIV to attach, penetrate, and replicate within a live animal by encoding said proteins into commensal organisms derived from gut associated lymphoid tissue using recombinant technology;
- b. creating and administering HIV related proteins necessary for HIV to evade said animal's immune response by encoding said HIV related proteins into commensal organisms derived from gut associated lymphoid tissue using recombinant technology;
- and
- c. infecting said animal with live, replication competent HIV.
A composition comprising:
- a. HIV related proteins necessary for a HIV virion to attach, penetrate, and replicate within a live animal, wherein said proteins are encoded in a genetically engineered commensal organism derived from gut associated lymphoid tissue using recombinant technology;
- b. HIV related proteins necessary for HIV to evade said animal's immune response, wherein said proteins are encoded in a genetically engineered commensal organism derived from gut associated lymphoid tissue using recombinant technology;
- and
- c. live, replication competent HIV.
Dependencies are inferred from the claim text.