Zebrafish models of acute myelogenous leukemia
OwnerRandall Peterson, Jing-Ruey Yehinventors
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Abstract
The invention provides zebrafish models of acute myelogenous leukemia (AML), as well as methods of using these models to identify therapeutic agents for treating AML.
Claims34
a method for identifying an agent that can be used in the treatment of acute:
- myelogenous leukemia (AML), the method comprising:
- (i) providing a zebrafish that expresses a gene product that induces a phenotype characteristic of AML,
- (ii) contacting the zebrafish with a candidate agent, and
- (iii) analyzing the effects of the agent on an AML-related phenotype of the zebrafish, wherein detection of an improvement in the phenotype indicates identification of an agent that can be used in the treatment of AML.
A zebrafish comprising a gene encoding a gene product that induces a phenotype characteristic of AML.
A method of identifying a therapeutic agent, the method comprising:
- (i) providing a zebrafish exhibiting a phenotype characteristic of a disease or condition,
- (ii) incubating the zebrafish in the presence of a candidate therapeutic agent, and
- (iii) monitoring the phenotype of the zebrafish using an automated system, wherein detection of an improvement in the phenotype indicates the identification of a therapeutic agent that can be used in the treatment of the disease or condition.
A method of treating AML in a patient, the method comprising increasing TIS11b levels in the patient.
A method for identifying an agent that can be used in the treatment of AML, the method comprising introducing a candidate agent into an expression system comprising a gene encoding TIS11b, and determining whether the candidate agent increases expression, stability, and/or activity of TIS11b.
Dependencies are inferred from the claim text.