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AssigneeTepha, Inc.
InventorsKlaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, David Martin, Simon Williams
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Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.
An absorbable biocompatible stent comprising a polymer composition that is plastically expandable at normal body temperature, and is of a first diameter sufficient to be retained upon a balloon catheter for placement within a body lumen, and is expandable to a second diameter sufficient to be retained within the body lumen.
A method to accelerate the degradation of a polymeric absorbable stent comprising blending poly-4-hydroxybutyrate or copolymers thereof with the polymeric composition.
Dependencies are inferred from the claim text.