System and methods of deep brain stimulation for post-operation patients

A system for programming a deep brain stimulator implanted in a target region of a brain of a living subject for optimal stimulation, wherein the deep brain stimulator comprises at least one electrode having a plurality of electrode contacts spaced apart from each other, and wherein any portion of the brain of the living subject is identifiable by a set of corresponding spatial coordinates, comprising:

• a. an efficacy atlas in which each position in the atlas coordinates of the efficacy atlas is associated with an efficacy of stimulation at a corresponding position in the spatial coordinates of the brain of the living subject;
• b. means for acquiring a position of each electrode contact of the at least one electrode in the spatial coordinates of the brain of the living subject;
• and
• c. a controller at least communicable with the efficacy atlas and adapted for mapping the acquired position of each electrode contact of the at least one electrode in the spatial coordinates of the brain of the living subject onto a corresponding position in the atlas coordinates of the efficacy atlas so as to determine the efficacy of stimulation at the acquired position in the spatial coordinates of the brain of the living subject, and selecting one or more electrode contacts having the highest efficacy for stimulation.

A system for programming a deep brain stimulator implanted in a target region of a brain of a living subject for optimal stimulation, wherein the deep brain stimulator comprises at least one electrode having a plurality of electrode contacts spaced apart from each other, and wherein any portion of the brain of the living subject is identifiable by a set of corresponding spatial coordinates, comprising:

• a. a data storage device;
• b. a database stored in the data storage device, comprising an electrophysiological atlas containing electrophysiological information acquired from each of the population of living subjects and related to atlas coordinates of the electrophysiological atlas;
• and
• c. a controller in communication with the data storage device and adapted for programmably interfacing with the database for creating an efficacy atlas in which a position in atlas coordinates of the efficacy atlas is related to a corresponding position in spatial coordinates of the brain of the living subject, and vice versa, and each position in atlas coordinates of the efficacy atlas is associated with an efficacy of stimulation at a corresponding position in spatial coordinates of the brain of the living subject.

Software stored on a computer readable medium for causing a computing system to perform functions comprising:

• a. creating an efficacy atlas in which a position in atlas coordinates of the efficacy atlas is related to a corresponding position in spatial coordinates of the brain of the living subject, and each position in the atlas coordinates of the efficacy atlas is associated with an efficacy of stimulation at a corresponding position in the spatial coordinates of the brain of the living subject;
• b. acquiring a position of each electrode contact of the at least one electrode in the spatial coordinates of the brain of the living subject;
• c. mapping the acquired position of each electrode contact of the at least one electrode in the spatial coordinates of the brain of the living subject onto a corresponding position in the atlas coordinates of the efficacy atlas so as to determine the efficacy of stimulation at the acquired position in the spatial coordinates of the brain of the living subject;
• and
• d. selecting one or more electrode contacts having the highest efficacy for stimulation.