Fluid, circuits, systems, and processes for extracorporeal blood processing

A method for performing renal replacement therapy with a treatment device that employs a fluid circuit with liquid and blood fluid circuits separated by a membrane, the membrane having a pore size effective to block the passage of pyrogenic material, the method comprising:

• connecting a source of electrolytically-balanced fluid to the liquid fluid circuit;
• ensuring sterility of the electrolytically-balanced fluid by passing the same through the membrane to produce sterile fluid and storing the sterile fluid in a reservoir;
• warming and maintaining a temperature of the sterile fluid until a treatment time;
• recirculating the sterile fluid through the reservoir during a first phase of priming to permit gas to be purged from the sterile fluid and prime a first portion of the fluid circuit;
• priming a further portion of the fluid circuit.

A method for performing renal replacement therapy with a treatment device that employs a fluid circuit with fluid and blood circuits separated by a membrane, the membrane having a pore size effective to block the passage of pyrogenic material, the method comprising:

• at a predetermined time prior to a treatment time, automatically preparing a batch of replacement fluid by filtering unfiltered replacement fluid with the membrane and storing filtered replacement fluid, resulting from the preparing, in a reservoir;
• initiating priming the fluid circuit with the filtered replacement fluid responsively to a signal indicating one of a passage of an interval of time, a mass of filtered replacement fluid, and a mass of unfiltered replacement fluid;
• initiating warming the filtered replacement fluid responsively to a predetermined time before the treatment time;
• initiating treating responsively to an indication of a completion of the priming.

A method for performing a blood treatment, comprising;

• providing a fluid circuit with a blood circuit and a non-blood circuit connected by a filter component having a porous membrane that separates the blood and non-blood circuits;
• the non-blood circuit including at least one connector and at least one pumping portion;
• the blood circuit having two access lines, each with line connectors being connected to the container to form a closed circuit;
• a single-chamber container, the two access line connectors being connected to the container to form a closed circuit;
• the blood circuit and container being hermetically isolated from an outside of the blood circuit and container except by a flow path through the porous membrane;
• sterilizing the fluid circuit, including the hermetically isolated blood circuit and container and providing it at a treatment site;
• flowing a treatment fluid through the non-blood circuit at least one connector into the container to fill it;
• disconnecting the two access line connectors from the container and connecting them to a patient access.