Heterocyclic compound
AssigneeMitsubishi Tanabe Pharma Corporation
InventorsAkira Kubo, Tetsu Nakane, Tatsuo Nakajima, Takanori Murakami, Hidetaka Miyoshi, Akihito Ogasawara
Life of this patent
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Abstract
The present invention is to provide a novel heterocyclic compound of the formula [I]: wherein R1 is a halogen, nitro, an alkyl, etc.; R2 is hydrogen, an alkyl, etc.; Ring A is 2-oxo-4-imidazolin-3,4-diyl, etc.; Ring B is a cycloalkyl, monocyclic saturated heterocyclic group; X is CH, N; Y is a single bond, CO, SO2; Z is O, NH, etc.; and Ring C is an aryl, a heterocyclic group, or a pharmaceutically acceptable salt thereof, which is useful as a p38 MAP kinase inhibitor.
Claims17
A compound of the formula [I]:
- wherein R1 is hydrogen, a halogen, nitro, an optionally substituted alkyl, an optionally substituted alkoxy, an optionally substituted amino, an optionally substituted carbamoyl, hydroxy or cyano,
- p is 1 or 2, provided that when p is 2, two R1s may be the same or different from each other,
- Z is oxygen atom or —N(R2)—,
- R2 is hydrogen, an alkyl or an alkanoyl,
- Ring A is a ring selected from the following formulae:
- R3, R4, R6, R7, R10 and R12 may be the same or different from each other, and each is (CH2)n—RA
- RA is hydrogen, an optionally substituted alkyl, an optionally substituted alkoxyalkyl, an optionally substituted cycloalkyl, an optionally substituted phenyl or an optionally substituted heterocyclic group,
- n is 0 or an integer of 1 to 4,
- R5, R8, R9, R11 and R13 to R24 may be the same or different from each other, and each is hydrogen, a halogen, an optionally substituted alkyl, alkoxy, alkanoyl, an alkoxycarbonyl, an optionally substituted amino, an optionally substituted carbamoyl, an optionally substituted cycloalkyl, an optionally substituted aryl or an optionally substituted heterocyclic group,
- Q1 is hydrogen, a halogen, cyano, an optionally substituted alkyl or an optionally substituted heterocyclic group,
- Ring B is a cycloalkane or a monocyclic saturated nitrogen-containing heterocyclic ring,
- X is CH or N,
- Y is a single bond, SO2 or CO,
- Ring C is an aromatic hydrocarbon ring or an optionally substituted heterocyclic ring,
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- wherein R1a is a halogen or an optionally substituted alkyl,
- p is 1 or 2, provided that when p is 2, two R1as may be the same or different from each other,
- R2 is hydrogen, an alkyl or an alkanoyl,
- RB is an optionally substituted alkyl or an optionally substituted heterocyclic group,
- Q1 is hydrogen, a halogen, cyano, an optionally substituted alkyl or an optionally substituted heterocyclic group,
- Ring B1 is a cycloalkane,
- X is CH or N,
- Ring C1 is an optionally substituted heterocyclic ring,
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.